Quick Summary
Clinical trials show Mounjaro produces greater average weight loss (15-20% body weight) compared to Wegovy (12-15%). Mounjaro targets two receptors (GLP-1 and GIP) vs Wegovy's single receptor (GLP-1). Both are effective, but individual results vary. Our pharmacist can help you choose the best option.
Is Mounjaro Better Than Wegovy?
Medical Review: Reviewed by registered pharmacist. Last Updated: December 2025. Location: Glasgow, Scotland.
Effectiveness Comparison
Both Mounjaro and Wegovy are highly effective weight loss medications, but clinical trials show some differences in results:
Weight Loss Results
Mounjaro
- • Average weight loss: 15-20% body weight
- • Dual-action (GLP-1 + GIP)
- • Superior results in clinical trials
- • FDA-approved for weight loss
Wegovy
- • Average weight loss: 12-15% body weight
- • Single-action (GLP-1)
- • Proven effective in clinical trials
- • FDA-approved for weight loss
How They Work Differently
Mounjaro (Tirzepatide)
Mounjaro is a dual-action medication that targets both:
- GLP-1 receptors: Regulates appetite and blood sugar
- GIP receptors: Enhances insulin secretion and appetite suppression
This dual-action mechanism may provide more effective appetite suppression and weight loss compared to single-receptor medications.
Wegovy (Semaglutide)
Wegovy is a single-action medication that targets:
- GLP-1 receptors: Regulates appetite and blood sugar
While targeting only one receptor, Wegovy has proven highly effective for weight loss and has been used successfully by many patients.
Side Effects Comparison
Both medications have similar side effect profiles:
- Nausea, vomiting, diarrhoea, constipation
- Abdominal pain or discomfort
- Decreased appetite (intended effect)
- Injection site reactions
Some patients report that Mounjaro may have slightly more gastrointestinal side effects due to its dual-action mechanism, but this varies by individual.
Which Should You Choose?
The best choice depends on several factors:
- Medical history: Some conditions may favour one medication over the other
- Previous treatment: If you've tried one without success, the other may be an option
- Side effect tolerance: Individual response to side effects varies
- Cost and availability: Pricing and insurance coverage may differ
- Pharmacist recommendation: Based on your specific needs
Our registered pharmacist will evaluate your medical history, current health status, and weight loss goals to help you choose the medication that's most appropriate for you.
Frequently Asked Questions
Which is more effective: Mounjaro or Wegovy?
Clinical trials show Mounjaro produces greater average weight loss (15-20% body weight) compared to Wegovy (12-15% body weight). Mounjaro targets two receptors (GLP-1 and GIP) compared to Wegovy's single receptor (GLP-1), which may contribute to superior results.
Do Mounjaro and Wegovy have the same side effects?
Both medications have similar side effects including nausea, vomiting, diarrhoea, and constipation. However, some patients report that Mounjaro may have slightly more gastrointestinal side effects due to its dual-action mechanism.
Can I switch from Wegovy to Mounjaro?
Yes, it's possible to switch from Wegovy to Mounjaro, but this should only be done under the supervision of your pharmacist. They will help you transition safely and determine the appropriate starting dose.
Which medication is more expensive?
Pricing varies, but both medications are similar in cost. Your pharmacist can discuss pricing options and help determine which treatment fits your budget. Some patients may find one medication more cost-effective based on their insurance coverage.
How do I choose between Mounjaro and Wegovy?
The best choice depends on your individual needs, medical history, and response to treatment. Our pharmacist will evaluate your situation and help you choose the medication that's most appropriate for you.
Not Sure Which Medication Is Right for You?
Our pharmacist will help you choose the best weight loss treatment for your needs
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