Mounjaro Contraindications: Who Should Not Take Mounjaro

Absolute Contraindications

Mounjaro should NOT be used in the following situations:

1. Medullary Thyroid Carcinoma (MTC)

Mounjaro is contraindicated in people with a personal or family history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN 2). Animal studies have shown an increased risk of thyroid tumours.

2. Multiple Endocrine Neoplasia Syndrome Type 2 (MEN 2)

People with MEN 2 syndrome should not take Mounjaro due to the increased risk of thyroid cancer associated with this condition.

3. Severe Gastrointestinal Disease

Mounjaro is contraindicated in people with severe gastrointestinal disease, including:

• Severe gastroparesis (delayed stomach emptying)
• Severe inflammatory bowel disease
• History of severe gastrointestinal complications

4. Pregnancy and Breastfeeding

Mounjaro should not be used during pregnancy or while breastfeeding. If you become pregnant while taking Mounjaro, contact your pharmacist immediately. Use effective contraception while on treatment.

5. Severe Allergic Reactions

Do not use Mounjaro if you have had a severe allergic reaction to tirzepatide or any component of Mounjaro.

Conditions Requiring Caution

Mounjaro should be used with caution in people with certain medical conditions. Your pharmacist will carefully evaluate your medical history before prescribing:

Pancreatitis

If you have a history of pancreatitis, Mounjaro should be used with caution. Your pharmacist will assess your risk and monitor you closely during treatment.

Kidney Disease

People with kidney disease may need dose adjustments or closer monitoring. Your pharmacist will evaluate your kidney function before and during treatment.

Type 2 Diabetes

While Mounjaro can be beneficial for people with type 2 diabetes, it may interact with other diabetes medications. Your pharmacist will review all your medications and may need to adjust doses of other diabetes treatments.

Gallbladder Disease

Rapid weight loss can increase the risk of gallbladder problems. If you have a history of gallbladder disease, your pharmacist will discuss the risks and benefits with you.

Medication Interactions

Mounjaro may interact with certain medications. Always inform your pharmacist about all medications you're taking, including:

• Other diabetes medications (may need dose adjustments)
• Blood thinners
• Oral medications (Mounjaro slows stomach emptying, which may affect absorption)
• Birth control pills (may be less effective)